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Paraxanthine

Paraxanthine suppliers and sourcing guide

Paraxanthine (1,7-dimethylxanthine) is a methylxanthine closely related to caffeine, differing by one methyl group. Commercial paraxanthine comes from a small number of manufacturers, made by chemical or biocatalytic processes and purified to a white crystalline powder; the production route should be stated on the supplier's specification. Much of the supply is sold under brand names with patent and licensing terms.

See suppliersWhat to ask for on the COA
Also known as
1,7-dimethylxanthine · 3,7-dihydro-1,7-dimethyl-1H-purine-2,6-dione · CAS 611-59-6
Facts checked
November 2026

Forms and grades of paraxanthine

Suppliers sell different products under the same name. Specify the one you need.

  • Purified paraxanthine

    Crystalline powder of high purity, the main traded form.

  • Branded ingredients

    Paraxanthine sold under a trademark, often with use terms, logo licensing and supplier documentation.

  • Diluted blends

    Paraxanthine pre-blended onto a carrier so milligram amounts can be mixed evenly.

  • Methylxanthine pre-blends

    Paraxanthine combined with caffeine or other ingredients at fixed ratios by the supplier.

What to check on the COA

Compare each result with your own specification when the lot arrives.

Assay (HPLC)
Paraxanthine purity by HPLC against a reference standard.
Related methylxanthines
Caffeine, theobromine and theophylline by HPLC, which shows the separation achieved and any carry-over from starting materials.
Identity
IR or NMR spectrum and HPLC retention time.
Residual solvents
Solvents from synthesis or purification, against USP <467> or the buyer's limits.
Loss on drying
Moisture against the supplier specification.
Heavy metals
Lead, arsenic, cadmium and mercury by ICP-MS, checked against the supplier specification and the buyer's own limits.

Storage, lots and expiry

Storage and shelf life

Store sealed in a cool, dry place protected from light. Keep pure material in clearly labeled, controlled storage because amounts per serving are small. Shelf life and retest date come from the supplier's specification.

Lots and expiry dates

Record assay and related methylxanthine results for each lot, and keep the supplier's production-route statement and any license terms with the lot file. Rotate first-expiry-first-out.

Regulatory status

Facts from regulators and standards bodies, each linked to its source.

  • Health Canada's Natural Health Products Ingredients Database lists paraxanthine (1,7-dimethylxanthine, CAS 611-59-6) as an approved chemical name, classified as an isolate under Schedule 1, item 2 of the Natural Health Products Regulations.

    Source: webprod.hc-sc.gc.ca (opens in a new tab)

This is general information, not regulatory advice. Status differs by country and by how the ingredient is used, so check the rules for your product and market.

Paraxanthine suppliers

Manufacturers and distributors whose own websites say they sell it.

We are checking paraxanthine suppliers now

Every listing is checked against the supplier’s own website before it goes live, so this list fills in over the coming weeks. The specs and COA checklist above are ready today.

Sell paraxanthine? Request a listing

Frequently asked questions

What forms of paraxanthine can brands buy?

Common forms include purified paraxanthine, branded ingredients, diluted blends and methylxanthine pre-blends. Ask each supplier for the specification sheet of the exact grade they quote.

What should the COA for paraxanthine include?

Expect assay (HPLC), related methylxanthines, identity, residual solvents, loss on drying and heavy metals, each with its method, specification and result for that lot.

How should paraxanthine be stored?

Store sealed in a cool, dry place protected from light. Keep pure material in clearly labeled, controlled storage because amounts per serving are small. Shelf life and retest date come from the supplier's specification.

What is the regulatory status of paraxanthine?

Health Canada's Natural Health Products Ingredients Database lists paraxanthine (1,7-dimethylxanthine, CAS 611-59-6) as an approved chemical name, classified as an isolate under Schedule 1, item 2 of the Natural Health Products Regulations.

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