NMN (nicotinamide mononucleotide)

NMN (nicotinamide mononucleotide) suppliers and sourcing guide

Nicotinamide mononucleotide (NMN) is a nucleotide made of nicotinamide, ribose and a phosphate group, a derivative of vitamin B3. Commercial NMN is produced mainly by enzymatic synthesis, in which enzymes join nicotinamide to a ribose phosphate donor, or by chemical synthesis, followed by purification and drying to a white powder. Brands usually buy high-purity beta-NMN powder, and the regulatory position differs by market and has changed over time.

See suppliers What to ask for on the COA

Category: Specialty nutrients
Also known as: Beta-nicotinamide mononucleotide · β-NMN · Nicotinamide ribotide
Facts checked: November 2026

Forms and grades of NMN (nicotinamide mononucleotide)

Suppliers sell different products under the same name. Specify the one you need.

Enzymatic NMN powder
Beta-NMN made with enzymes from nicotinamide and a ribose phosphate source, usually sold at 98% or higher purity.
Chemically synthesized NMN
NMN made by chemical routes; the specification should cover isomer purity and residual solvents from synthesis.
Encapsulated and stabilized forms
NMN coated or encapsulated (for example in liposomes) for capsules and drink mixes; carriers lower the NMN percentage per gram.
Reduced NMN (NMNH)
The reduced form, sold by a few suppliers as a separate ingredient with its own specification.

What to check on the COA

Compare each result with your own specification when the lot arrives.

Assay (HPLC): Beta-NMN content by HPLC against a reference standard.
Related substances: Nicotinamide, NAD and other nucleotides by HPLC; nicotinamide rises as NMN breaks down, so it is the main stability marker.
Water (Karl Fischer): NMN is hygroscopic, and moisture speeds breakdown.
Identity: HPLC retention time, IR or NMR compared with a reference standard, and the alpha/beta form where the supplier reports it.
Residual solvents: Solvents used in purification or synthesis, against USP <467> or the buyer's limits.
Heavy metals and microbiology: Lead, arsenic, cadmium and mercury by ICP-MS, plus total plate count, yeast and mold, and pathogens; enzymatic grades may also report residual enzyme or endotoxin.

Storage, lots and expiry

Storage and shelf life

Keep NMN sealed with desiccant, protected from moisture and heat; many suppliers recommend refrigerated storage, so follow the specification. Reseal opened containers quickly, since NMN absorbs water and breaks down to nicotinamide. Shelf life is set by the supplier and confirmed by retesting assay and nicotinamide.

Lots and expiry dates

Record assay, water and nicotinamide for each lot, and recheck older stock, because nicotinamide climbs with age and warm storage. Keep the production route (enzymatic or chemical) on lot records.

Regulatory status

Facts from regulators and standards bodies, each linked to its source.

Health Canada's Multi-Vitamin/Mineral Supplements monograph added nicotinamide mononucleotide as a medicinal ingredient in its Table 3.
Source: webprod.hc-sc.gc.ca (opens in a new tab)
The same monograph says that when niacin, niacinamide and NMN are combined, the total daily quantity must not exceed the niacin/niacinamide maximum of 500 mg/day.
Source: webprod.hc-sc.gc.ca (opens in a new tab)
FDA's list of reviewed 75-day premarket notifications for new dietary ingredients includes NDIN 1444, beta-nicotinamide mononucleotide (β-NMN), from Effepharm, Ltd.; the list does not state the outcome.
Source: fda.gov (opens in a new tab)

This is general information, not regulatory advice. Status differs by country and by how the ingredient is used, so check the rules for your product and market.

NMN (nicotinamide mononucleotide) suppliers

Manufacturers and distributors whose own websites say they sell it.

We are checking NMN (nicotinamide mononucleotide) suppliers now

Every listing is checked against the supplier’s own website before it goes live, so this list fills in over the coming weeks. The specs and COA checklist above are ready today.

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Frequently asked questions

What forms of NMN (nicotinamide mononucleotide) can brands buy?

Common forms include enzymatic NMN powder, chemically synthesized NMN, encapsulated and stabilized forms and reduced NMN (NMNH). Ask each supplier for the specification sheet of the exact grade they quote.

What should the COA for NMN (nicotinamide mononucleotide) include?

Expect assay (HPLC), related substances, water (Karl Fischer), identity, residual solvents and heavy metals and microbiology, each with its method, specification and result for that lot.

How should NMN (nicotinamide mononucleotide) be stored?

What is the regulatory status of NMN (nicotinamide mononucleotide)?

Health Canada's Multi-Vitamin/Mineral Supplements monograph added nicotinamide mononucleotide as a medicinal ingredient in its Table 3. The same monograph says that when niacin, niacinamide and NMN are combined, the total daily quantity must not exceed the niacin/niacinamide maximum of 500 mg/day. FDA's list of reviewed 75-day premarket notifications for new dietary ingredients includes NDIN 1444, beta-nicotinamide mononucleotide (β-NMN), from Effepharm, Ltd.; the list does not state the outcome.

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