Nattokinase
Nattokinase is a serine protease enzyme produced by Bacillus subtilis var. natto, the bacterium used to ferment soybeans into natto. Commercial nattokinase is made by fermenting soybeans or another medium with the bacterium, then extracting, concentrating and drying the enzyme, usually onto a carrier. It is sold by enzyme activity in fibrin units per gram, and many grades are processed to remove the vitamin K2 (menaquinone-7) that natto naturally contains.
Suppliers sell different products under the same name. Specify the one you need.
Powders at a stated activity, such as 20,000 fibrin units per gram, on a carrier like maltodextrin or dextrin.
Nattokinase processed to remove menaquinone-7, with K2 content stated on the specification.
Grades from non-GMO soybeans or from fermentation on non-soy media, where offered.
Granules or coated particles for tableting and to protect activity during processing.
Compare each result with your own specification when the lot arrives.
Store sealed in a cool, dry place; activity drops with heat and humidity, and some suppliers specify refrigeration. Keep containers closed between uses. Shelf life and retest date come from the supplier, with enzyme activity repeated at retest.
Record enzyme activity and K2 content for each lot and adjust batch amounts to the measured activity. Many brands add an overage to cover activity loss over shelf life; base it on stability data. Rotate first-expiry-first-out.
Facts from regulators and standards bodies, each linked to its source.
Health Canada's Natural Health Products Ingredients Database lists nattokinase as an approved protein name, with Bacillus subtilis var. natto and soybean (Glycine max) seed as source materials.
Source: webprod.hc-sc.gc.ca (opens in a new tab)The same entry classifies nattokinase as an isolate under Schedule 1, item 2 of the Natural Health Products Regulations.
Source: webprod.hc-sc.gc.ca (opens in a new tab)This is general information, not regulatory advice. Status differs by country and by how the ingredient is used, so check the rules for your product and market.
Manufacturers and distributors whose own websites say they sell it.
Manufacturer · Thane, India
Indian maker of enzymes and probiotics produced by fermentation, with a human nutrition range of digestive and systemic enzymes plus Saccharomyces boulardii for supplement makers.
Suppliers are in alphabetical order and none pays to appear. Each claim is checked against the supplier’s own website on the date shown. Ask for the specification sheet and a recent COA before you order, and confirm details with the supplier.
Common forms include standard activity powders, vitamin K2-free grades, non-GMO or soy-free grades and coated or granulated grades. Ask each supplier for the specification sheet of the exact grade they quote.
Expect enzyme activity, vitamin K2 content, moisture, allergen statement, heavy metals and microbiology, each with its method, specification and result for that lot.
Store sealed in a cool, dry place; activity drops with heat and humidity, and some suppliers specify refrigeration. Keep containers closed between uses. Shelf life and retest date come from the supplier, with enzyme activity repeated at retest.
Health Canada's Natural Health Products Ingredients Database lists nattokinase as an approved protein name, with Bacillus subtilis var. natto and soybean (Glycine max) seed as source materials. The same entry classifies nattokinase as an isolate under Schedule 1, item 2 of the Natural Health Products Regulations.
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