DIM (diindolylmethane)
DIM (diindolylmethane) suppliers and sourcing guide
DIM (3,3'-diindolylmethane) is a compound formed from indole-3-carbinol, which in turn comes from glucobrassicin in cruciferous vegetables such as broccoli and cabbage. Commercial DIM is almost always made by chemical synthesis and purified to an off-white to tan crystalline powder. Because pure DIM barely dissolves in water, it is also sold in formulated forms on carriers such as starch, phosphatidylcholine or vitamin E TPGS.
- Category
- Specialty nutrients
- Also known as
- 3,3'-diindolylmethane · 3,3'-methylenebis-1H-indole · DIM · CAS 1968-05-4
- Facts checked
- November 2026
Forms and grades of DIM (diindolylmethane)
Suppliers sell different products under the same name. Specify the one you need.
Pure crystalline DIM
High-purity synthetic powder, the usual starting material for capsules.
Formulated or microencapsulated DIM
DIM at a stated percentage on a carrier to make it disperse in water; dose by DIM content, not blend weight.
Oil-dispersible forms
DIM dissolved or suspended in oil for softgels.
Plant-isolated DIM
DIM from Brassica vegetables, offered rarely; Health Canada lists both plant isolate and synthetic sources.
What to check on the COA
Compare each result with your own specification when the lot arrives.
- Assay (HPLC)
- DIM content by HPLC against a reference standard; for formulated grades, the percentage DIM in the blend.
- Related substances
- Residual indole-3-carbinol, indole and oligomers by HPLC.
- Identity and melting point
- IR spectrum and melting range.
- Residual solvents
- Solvents from synthesis and crystallization, against USP <467> or the buyer's limits.
- Heavy metals
- Lead, arsenic, cadmium and mercury by ICP-MS, checked against the supplier specification and the buyer's own limits.
- Microbiology
- Total plate count, yeast and mold, coliforms or E. coli, and Salmonella, against the supplier specification.
Storage, lots and expiry
Storage and shelf life
Store sealed in a cool, dry place and protect from light and air, since DIM can discolor on exposure. Formulated grades follow the carrier's storage needs, for example lower temperatures for lipid-based forms. Shelf life and retest date come from the supplier's specification.
Lots and expiry dates
Record the DIM percentage of each lot, especially for formulated grades where it varies, and recalculate batch amounts when it changes. Note color at receipt; darker material can signal age or degradation.
Regulatory status
Facts from regulators and standards bodies, each linked to its source.
Health Canada's DIM monograph lists 3,3'-diindolylmethane either as an isolate from Brassica oleracea varieties (cauliflower, cabbage, Brussels sprouts and broccoli) or from a synthetic source.
Source: webprod.hc-sc.gc.ca (opens in a new tab)The monograph's doses for adults 18 years and older do not exceed 200 milligrams of DIM per day.
Source: webprod.hc-sc.gc.ca (opens in a new tab)The EU Novel Food Catalogue entry for DIM covers only the synthetic form, and records Finland confirming novel food status for synthetic DIM.
Source: ec.europa.eu (opens in a new tab)
This is general information, not regulatory advice. Status differs by country and by how the ingredient is used, so check the rules for your product and market.
DIM (diindolylmethane) suppliers
Manufacturers and distributors whose own websites say they sell it.
We are checking DIM (diindolylmethane) suppliers now
Every listing is checked against the supplier’s own website before it goes live, so this list fills in over the coming weeks. The specs and COA checklist above are ready today.
Sell DIM (diindolylmethane)? Request a listingFrequently asked questions
What forms of DIM (diindolylmethane) can brands buy?
Common forms include pure crystalline DIM, formulated or microencapsulated DIM, oil-dispersible forms and plant-isolated DIM. Ask each supplier for the specification sheet of the exact grade they quote.
What should the COA for DIM (diindolylmethane) include?
Expect assay (HPLC), related substances, identity and melting point, residual solvents, heavy metals and microbiology, each with its method, specification and result for that lot.
How should DIM (diindolylmethane) be stored?
Store sealed in a cool, dry place and protect from light and air, since DIM can discolor on exposure. Formulated grades follow the carrier's storage needs, for example lower temperatures for lipid-based forms. Shelf life and retest date come from the supplier's specification.
What is the regulatory status of DIM (diindolylmethane)?
Health Canada's DIM monograph lists 3,3'-diindolylmethane either as an isolate from Brassica oleracea varieties (cauliflower, cabbage, Brussels sprouts and broccoli) or from a synthetic source. The monograph's doses for adults 18 years and older do not exceed 200 milligrams of DIM per day. The EU Novel Food Catalogue entry for DIM covers only the synthetic form, and records Finland confirming novel food status for synthetic DIM.
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