D-ribose
D-ribose is a five-carbon sugar (a pentose) that forms the backbone of RNA and occurs in all living cells. Commercial D-ribose is made by fermenting glucose with selected Bacillus strains, then recovering, purifying and crystallizing it to a white powder. Brands buy it as crystalline powder for drink mixes, capsules and chewables.
Suppliers sell different products under the same name. Specify the one you need.
Standard white powder, the main traded form.
Larger particles for better flow and faster wetting in drink mixes.
Grades sold under a trademark with supplier dossiers.
D-ribose pre-blended with other ingredients by the supplier.
Compare each result with your own specification when the lot arrives.
Store sealed in a cool, dry place; D-ribose absorbs moisture, cakes and can brown with heat. Shelf life and retest date come from the supplier's specification, with assay, moisture and color checked at retest.
Record assay, moisture and color for each lot. Check older lots for caking and color before use, and rotate first-expiry-first-out.
Facts from regulators and standards bodies, each linked to its source.
FDA's GRAS Notice Inventory lists GRN 243 for D-ribose, notified by Bioenergy, Inc. for use in several food categories under conditions stated in the notice; it closed on November 10, 2008 with FDA having no questions.
Source: hfpappexternal.fda.gov (opens in a new tab)An earlier notice from the same company, GRN 100, for use in food in general, closed in 2002 with FDA finding that the notice did not provide a basis for a GRAS determination.
Source: hfpappexternal.fda.gov (opens in a new tab)FDA's Substances Added to Food inventory lists D-ribose with the technical effect "flavoring agent or adjuvant" (FEMA No. 3793).
Source: hfpappexternal.fda.gov (opens in a new tab)The EU Novel Food Catalogue entry for D-ribose records member state use as a food supplement.
Source: ec.europa.eu (opens in a new tab)This is general information, not regulatory advice. Status differs by country and by how the ingredient is used, so check the rules for your product and market.
Manufacturers and distributors whose own websites say they sell it.
Distributor · City of Industry, CA
California ingredient supplier that sources branded and commodity ingredients for supplement and food makers, from amino acids and vitamins to magnesium L-threonate and a plant-based vitamin D3.
Suppliers are in alphabetical order and none pays to appear. Each claim is checked against the supplier’s own website on the date shown. Ask for the specification sheet and a recent COA before you order, and confirm details with the supplier.
Common forms include crystalline powder, granular or agglomerated grades, branded D-ribose and blends. Ask each supplier for the specification sheet of the exact grade they quote.
Expect assay (HPLC), specific rotation, loss on drying, color and appearance, heavy metals and microbiology, each with its method, specification and result for that lot.
Store sealed in a cool, dry place; D-ribose absorbs moisture, cakes and can brown with heat. Shelf life and retest date come from the supplier's specification, with assay, moisture and color checked at retest.
FDA's GRAS Notice Inventory lists GRN 243 for D-ribose, notified by Bioenergy, Inc. for use in several food categories under conditions stated in the notice; it closed on November 10, 2008 with FDA having no questions. An earlier notice from the same company, GRN 100, for use in food in general, closed in 2002 with FDA finding that the notice did not provide a basis for a GRAS determination. FDA's Substances Added to Food inventory lists D-ribose with the technical effect "flavoring agent or adjuvant" (FEMA No. 3793). The EU Novel Food Catalogue entry for D-ribose records member state use as a food supplement.
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