Choline bitartrate
Choline bitartrate is the salt of choline with L-tartaric acid. It is made synthetically: choline base, produced from trimethylamine and ethylene oxide, is neutralized with tartaric acid and the salt is crystallized and dried. It is a white crystalline powder that is about 41% choline by weight, and it is the most widely used choline source in tablets, capsules and powder blends.
Suppliers sell different products under the same name. Specify the one you need.
Crystalline powder for blending and capsule fill.
Granulated material with better flow for tableting.
Grades coated with fat or other materials to cut moisture pickup and the fishy odor that develops in blends.
Choline bitartrate pre-blended with carriers or other nutrients for multi-ingredient products.
Compare each result with your own specification when the lot arrives.
Store sealed in moisture-barrier packaging in a cool, dry place; choline bitartrate absorbs moisture, cakes and develops a fishy odor when damp or warm. Reseal opened containers and keep humidity low in blending rooms. Shelf life or retest date is set by the supplier's specification.
Record assay and moisture for each lot and note any odor at receiving. Because choline content is about 41% of the salt, keep the conversion factor used for label math in the lot record, and rotate first-expiry-first-out.
Facts from regulators and standards bodies, each linked to its source.
21 CFR 182.8250 lists choline bitartrate as generally recognized as safe when used in accordance with good manufacturing practice.
Source: ecfr.gov (opens in a new tab)21 CFR 101.9(c)(8)(iv) sets the Reference Daily Intake for choline at 550 milligrams for adults and children 4 years and older.
Source: ecfr.gov (opens in a new tab)Health Canada's Multi-Vitamin/Mineral Supplements monograph lists choline bitartrate among the source ingredients for choline.
Source: webprod.hc-sc.gc.ca (opens in a new tab)This is general information, not regulatory advice. Status differs by country and by how the ingredient is used, so check the rules for your product and market.
Manufacturers and distributors whose own websites say they sell it.
Distributor · City of Industry, CA
California ingredient supplier that sources branded and commodity ingredients for supplement and food makers, from amino acids and vitamins to magnesium L-threonate and a plant-based vitamin D3.
Suppliers are in alphabetical order and none pays to appear. Each claim is checked against the supplier’s own website on the date shown. Ask for the specification sheet and a recent COA before you order, and confirm details with the supplier.
Common forms include standard powder, granular or direct-compression grades, coated or encapsulated and choline premixes. Ask each supplier for the specification sheet of the exact grade they quote.
Expect assay (titration or HPLC), identity, loss on drying, residue on ignition and pH, trimethylamine or odor and heavy metals, each with its method, specification and result for that lot.
Store sealed in moisture-barrier packaging in a cool, dry place; choline bitartrate absorbs moisture, cakes and develops a fishy odor when damp or warm. Reseal opened containers and keep humidity low in blending rooms. Shelf life or retest date is set by the supplier's specification.
21 CFR 182.8250 lists choline bitartrate as generally recognized as safe when used in accordance with good manufacturing practice. 21 CFR 101.9(c)(8)(iv) sets the Reference Daily Intake for choline at 550 milligrams for adults and children 4 years and older. Health Canada's Multi-Vitamin/Mineral Supplements monograph lists choline bitartrate among the source ingredients for choline.
Request a free listing for the ingredients you make or distribute. No paid placement.