Betaine anhydrous
Betaine anhydrous suppliers and sourcing guide
Betaine (trimethylglycine) is a small amino acid derivative found in sugar beets and other plants. Natural betaine anhydrous is recovered from sugar beet molasses or vinasse by chromatographic separation and crystallization; synthetic betaine is made from trimethylamine and chloroacetic acid. It is a white, hygroscopic crystalline powder. Betaine hydrochloride is a different, acidic salt and is sold separately.
- Category
- Specialty nutrients
- Also known as
- trimethylglycine · TMG · glycine betaine · N,N,N-trimethylglycine
- Facts checked
- November 2026
Forms and grades of betaine anhydrous
Suppliers sell different products under the same name. Specify the one you need.
Natural betaine anhydrous (beet-derived)
Crystallized from sugar beet byproducts, often 97% to 99% purity.
Synthetic betaine anhydrous
Made by chemical synthesis; generally sold for feed and some food uses.
Betaine monohydrate
Hydrated crystal form with lower betaine per gram.
Granular grades
Agglomerated betaine with better flow for tableting and blending.
What to check on the COA
Compare each result with your own specification when the lot arrives.
- Betaine assay (HPLC or titration)
- Betaine content on a dry basis by HPLC or non-aqueous titration.
- Identity
- IR spectrum against a reference standard.
- Loss on drying
- Moisture; anhydrous betaine is very hygroscopic.
- Residue on ignition and chloride
- Inorganic residue and chloride, which flag hydrochloride or salt carryover.
- Heavy metals
- Lead, arsenic, cadmium and mercury by ICP-MS, checked against the supplier specification and the buyer's own limits.
- Microbiology
- Total plate count, yeast and mold, coliforms or E. coli, and Salmonella, against the supplier specification.
Storage, lots and expiry
Storage and shelf life
Betaine anhydrous pulls in moisture fast, so store it sealed in moisture-barrier packaging in a dry room and reseal opened bags immediately. Caked material may need milling before use. Shelf life and retest come from the supplier's specification.
Lots and expiry dates
Record the source (beet-derived or synthetic), form (anhydrous or monohydrate) and assay for each lot, since they change betaine per gram. Check moisture at receipt and rotate first-expiry-first-out.
Regulatory status
Facts from regulators and standards bodies, each linked to its source.
FDA's Substances Added to Food inventory lists betaine, including betaine anhydrous and trimethylglycine as other names, with the technical effect flavoring agent or adjuvant.
Source: hfpappexternal.fda.gov (opens in a new tab)Health Canada's Betaine / Betaine Hydrochloride monograph lists betaine (common names betaine anhydrous and trimethylglycine) from sugar beet (Beta vulgaris) root isolate or a synthetic source.
Source: webprod.hc-sc.gc.ca (opens in a new tab)The EU Novel Food Catalogue entry for betaine (POL-NF-09241) lists the substance as not novel in food supplements and also as an authorised novel food.
Source: ec.europa.eu (opens in a new tab)
This is general information, not regulatory advice. Status differs by country and by how the ingredient is used, so check the rules for your product and market.
Betaine anhydrous suppliers
Manufacturers and distributors whose own websites say they sell it.
We are checking betaine anhydrous suppliers now
Every listing is checked against the supplier’s own website before it goes live, so this list fills in over the coming weeks. The specs and COA checklist above are ready today.
Sell betaine anhydrous? Request a listingFrequently asked questions
What forms of betaine anhydrous can brands buy?
Common forms include natural betaine anhydrous (beet-derived), synthetic betaine anhydrous, betaine monohydrate and granular grades. Ask each supplier for the specification sheet of the exact grade they quote.
What should the COA for betaine anhydrous include?
Expect betaine assay (HPLC or titration), identity, loss on drying, residue on ignition and chloride, heavy metals and microbiology, each with its method, specification and result for that lot.
How should betaine anhydrous be stored?
Betaine anhydrous pulls in moisture fast, so store it sealed in moisture-barrier packaging in a dry room and reseal opened bags immediately. Caked material may need milling before use. Shelf life and retest come from the supplier's specification.
What is the regulatory status of betaine anhydrous?
FDA's Substances Added to Food inventory lists betaine, including betaine anhydrous and trimethylglycine as other names, with the technical effect flavoring agent or adjuvant. Health Canada's Betaine / Betaine Hydrochloride monograph lists betaine (common names betaine anhydrous and trimethylglycine) from sugar beet (Beta vulgaris) root isolate or a synthetic source. The EU Novel Food Catalogue entry for betaine (POL-NF-09241) lists the substance as not novel in food supplements and also as an authorised novel food.
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