Alpha-GPC
Alpha-GPC (L-alpha-glycerylphosphorylcholine, choline alfoscerate) is a water-soluble choline compound made of glycerol, phosphate and choline. Commercial material is made either by removing the fatty acids from soy or sunflower lecithin phosphatidylcholine, or by chemical synthesis, then purified. It is very hygroscopic, so it is sold as a 50% powder on a silica or other carrier, or as a concentrated liquid of about 85% or more.
Suppliers sell different products under the same name. Specify the one you need.
Alpha-GPC on a carrier such as silicon dioxide, the usual form for capsules and tablets.
Concentrated aqueous solution for liquids, softgels and further processing.
Made from soy or sunflower phosphatidylcholine; may need source and allergen documentation.
Made by chemical synthesis; specify residual solvent and impurity limits.
Compare each result with your own specification when the lot arrives.
Alpha-GPC is strongly hygroscopic: keep powder in sealed, moisture-barrier packaging with desiccant in a cool, dry room, and close opened containers right away. Liquid grades should be kept sealed at controlled room temperature. Shelf life and retest come from the supplier's specification.
Assay can read low if a powder has taken up water, so record water content and assay together for each lot. Note the carrier, the source (lecithin-derived or synthetic) and the percentage grade, and rotate first-expiry-first-out.
Facts from regulators and standards bodies, each linked to its source.
GRN 419, for L-alpha-glycerylphosphorylcholine notified by ChemiNutra, Inc. as a source of choline in listed beverages and foods, closed on November 20, 2012 with FDA having no questions.
Source: hfpappexternal.fda.gov (opens in a new tab)The EU Novel Food Catalogue entry POL-NF-00440 records the Czech competent authority's conclusion that L-alpha-GPC is a novel food, with the status not yet authorised.
Source: ec.europa.eu (opens in a new tab)A Health Canada multi-ingredient natural health product monograph lists L-alpha-glycerylphosphorylcholine (choline alfoscerate) as a medicinal ingredient.
Source: webprod.hc-sc.gc.ca (opens in a new tab)This is general information, not regulatory advice. Status differs by country and by how the ingredient is used, so check the rules for your product and market.
Manufacturers and distributors whose own websites say they sell it.
Manufacturer · Austin, TX
Sells it as AlphaSize
US arm of Italian drug maker Italfarmaco that sells branded alpha-GPC and phosphatidylserine to supplement, food and beverage brands, shipping from a warehouse in Austin, Texas.
Suppliers are in alphabetical order and none pays to appear. Each claim is checked against the supplier’s own website on the date shown. Ask for the specification sheet and a recent COA before you order, and confirm details with the supplier.
Common forms include alpha-GPC 50% powder, alpha-GPC liquid (about 85% to 99%), lecithin-derived and synthetic. Ask each supplier for the specification sheet of the exact grade they quote.
Expect assay (HPLC), identity, water content, residual solvents, heavy metals and microbiology, each with its method, specification and result for that lot.
Alpha-GPC is strongly hygroscopic: keep powder in sealed, moisture-barrier packaging with desiccant in a cool, dry room, and close opened containers right away. Liquid grades should be kept sealed at controlled room temperature. Shelf life and retest come from the supplier's specification.
GRN 419, for L-alpha-glycerylphosphorylcholine notified by ChemiNutra, Inc. as a source of choline in listed beverages and foods, closed on November 20, 2012 with FDA having no questions. The EU Novel Food Catalogue entry POL-NF-00440 records the Czech competent authority's conclusion that L-alpha-GPC is a novel food, with the status not yet authorised. A Health Canada multi-ingredient natural health product monograph lists L-alpha-glycerylphosphorylcholine (choline alfoscerate) as a medicinal ingredient.
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