Thiamine hydrochloride
Thiamine hydrochloride is the chloride-hydrochloride salt of thiamine (vitamin B1), a white crystalline powder with a slight yeast-like odor. It is made by chemical synthesis: the pyrimidine and thiazole ring systems are built separately and then linked, and the product is crystallized as the hydrochloride. It is very soluble in water and somewhat hygroscopic, which suits liquids and beverages, while the mononitrate is usually chosen for dry products.
Suppliers sell different products under the same name. Specify the one you need.
Fine crystalline powder tested to pharmacopeia or Food Chemicals Codex monographs, for supplements, foods and beverages.
Larger or granulated particles that flow and compress better in tablets.
Thiamine hydrochloride coated with fat or ethylcellulose to reduce odor, taste and moisture pickup in premixes.
Lower-cost grade for animal nutrition; not meant for human food or supplements.
Compare each result with your own specification when the lot arrives.
Thiamine hydrochloride absorbs moisture, so store it tightly closed in a cool, dry place away from light. It is most stable in acidic conditions and breaks down with heat in neutral or alkaline products, and sulfites destroy it, which matters for finished-product stability. Suppliers give a retest or expiry date, with assay and water as the usual retest checks.
Record assay and water content for each lot, since moisture pickup changes the thiamine delivered per kilogram. Keep coated and uncoated grades as separate items and rotate FEFO.
Facts from regulators and standards bodies, each linked to its source.
21 CFR 184.1875 affirms thiamine hydrochloride as GRAS as a flavoring agent and adjuvant or a nutrient supplement, used in food with no limitation other than current good manufacturing practice.
Source: ecfr.gov (opens in a new tab)Health Canada's Multi-Vitamin/Mineral Supplements monograph lists thiamine hydrochloride as a source ingredient for thiamine (vitamin B1).
Source: webprod.hc-sc.gc.ca (opens in a new tab)21 CFR 101.9(c)(8)(iv) sets the Reference Daily Intake for thiamin at 1.2 mg for adults and children 4 years and older.
Source: ecfr.gov (opens in a new tab)This is general information, not regulatory advice. Status differs by country and by how the ingredient is used, so check the rules for your product and market.
Manufacturers and distributors whose own websites say they sell it.
Manufacturer · Nanjing, China
Nanjing-based maker and marketer of ingredients for food, nutrition, personal care and feed. Its food and nutrition range includes vitamin C and the main B vitamins in several forms.
Suppliers are in alphabetical order and none pays to appear. Each claim is checked against the supplier’s own website on the date shown. Ask for the specification sheet and a recent COA before you order, and confirm details with the supplier.
Common forms include uSP / FCC / Ph. Eur. grade, granular or direct-compression grade, coated grade and feed grade. Ask each supplier for the specification sheet of the exact grade they quote.
Expect assay, identity, water (Karl Fischer), pH of solution, residue on ignition and heavy metals, each with its method, specification and result for that lot.
Thiamine hydrochloride absorbs moisture, so store it tightly closed in a cool, dry place away from light. It is most stable in acidic conditions and breaks down with heat in neutral or alkaline products, and sulfites destroy it, which matters for finished-product stability. Suppliers give a retest or expiry date, with assay and water as the usual retest checks.
21 CFR 184.1875 affirms thiamine hydrochloride as GRAS as a flavoring agent and adjuvant or a nutrient supplement, used in food with no limitation other than current good manufacturing practice. Health Canada's Multi-Vitamin/Mineral Supplements monograph lists thiamine hydrochloride as a source ingredient for thiamine (vitamin B1). 21 CFR 101.9(c)(8)(iv) sets the Reference Daily Intake for thiamin at 1.2 mg for adults and children 4 years and older.
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