Saccharomyces boulardii
Saccharomyces boulardii is a yeast, genetically a subtype of Saccharomyces cerevisiae rather than a separate species, sold as a live probiotic. It is grown by aerobic fermentation, harvested, mixed with protectants and freeze-dried to a powder of live yeast cells. Brands buy a named strain at a stated CFU per gram; because it is a yeast, it is counted on yeast media and is distinct from baker's or brewer's yeast strains of S. cerevisiae.
Suppliers sell different products under the same name. Specify the one you need.
Lyophilized live yeast at a stated count in billions of CFU per gram, as concentrate or diluted with a carrier such as maltodextrin.
A specific strain identified by a culture-collection deposit number, sold with that strain's own documentation; the strain belongs on the specification.
Pre-blended with lactobacilli or bifidobacteria; ask for separate counts for the yeast and each bacterial strain.
Yeast cells coated or filled into acid-resistant capsules to limit moisture and acid exposure during storage and processing.
Compare each result with your own specification when the lot arrives.
Keep freeze-dried yeast sealed in moisture- and oxygen-barrier packs with desiccant, cool and dry, refrigerated if the supplier's specification calls for it. Let cold packs reach room temperature before opening and reseal at once. Shelf life is set by the supplier from real-time viable count stability data, and aged stock is retested for count before use.
Record the actual CFU/g and strain for each lot, since counts vary and set the amount per batch. Rotate stock FEFO and size the overage from your own finished-product stability data.
Facts from regulators and standards bodies, each linked to its source.
Health Canada's Probiotics monograph lists Saccharomyces boulardii as a medicinal ingredient, and the licence application and label must give the strain designation.
Source: webprod.hc-sc.gc.ca (opens in a new tab)The monograph notes that Saccharomyces boulardii is not a valid name for a subtype of Saccharomyces cerevisiae but is still accepted as a proper name in probiotic products.
Source: webprod.hc-sc.gc.ca (opens in a new tab)FDA's draft guidance on dietary supplements containing live microbials states its intent to exercise enforcement discretion so that firms may declare live microbial quantity in colony forming units (CFUs), in addition to the weight declaration required by regulation.
Source: fda.gov (opens in a new tab)This is general information, not regulatory advice. Status differs by country and by how the ingredient is used, so check the rules for your product and market.
Manufacturers and distributors whose own websites say they sell it.
Manufacturer · Thane, India
Indian maker of enzymes and probiotics produced by fermentation, with a human nutrition range of digestive and systemic enzymes plus Saccharomyces boulardii for supplement makers.
Manufacturer · Hyderabad, India
Indian probiotic manufacturer in Hyderabad’s Genome Valley that supplies spore-forming and other probiotic strains in bulk and as contract-made finished formats.
Suppliers are in alphabetical order and none pays to appear. Each claim is checked against the supplier’s own website on the date shown. Ask for the specification sheet and a recent COA before you order, and confirm details with the supplier.
Common forms include freeze-dried powder, named strain, combination with bacterial strains and encapsulated or coated. Ask each supplier for the specification sheet of the exact grade they quote.
Expect viable count (CFU/g), identity, bacterial contaminants, moisture or water activity and heavy metals, each with its method, specification and result for that lot.
Keep freeze-dried yeast sealed in moisture- and oxygen-barrier packs with desiccant, cool and dry, refrigerated if the supplier's specification calls for it. Let cold packs reach room temperature before opening and reseal at once. Shelf life is set by the supplier from real-time viable count stability data, and aged stock is retested for count before use.
Health Canada's Probiotics monograph lists Saccharomyces boulardii as a medicinal ingredient, and the licence application and label must give the strain designation. The monograph notes that Saccharomyces boulardii is not a valid name for a subtype of Saccharomyces cerevisiae but is still accepted as a proper name in probiotic products. FDA's draft guidance on dietary supplements containing live microbials states its intent to exercise enforcement discretion so that firms may declare live microbial quantity in colony forming units (CFUs), in addition to the weight declaration required by regulation.
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