Inositol hexanicotinate
Inositol hexanicotinate suppliers and sourcing guide
Inositol hexanicotinate is an ester in which all six hydroxyl groups of myo-inositol are bound to nicotinic acid (niacin). It is made by reacting inositol with nicotinic acid or a nicotinoyl derivative, then purifying and drying the product to a white, nearly water-insoluble powder. Brands buy it as a source of niacin for tablets and capsules.
- Category
- Vitamins and minerals
- Also known as
- Inositol hexaniacinate · myo-Inositol hexanicotinate · Inositol nicotinate
- Facts checked
- November 2026
Forms and grades of inositol hexanicotinate
Suppliers sell different products under the same name. Specify the one you need.
USP or pharmaceutical grade powder
The standard white powder with assay stated on the dried basis.
Granulated grades
Granules for direct compression.
Blends
Combined with other B vitamins in premixes at a stated niacin equivalent.
What to check on the COA
Compare each result with your own specification when the lot arrives.
- Assay
- Inositol hexanicotinate content by HPLC on the dried basis.
- Free nicotinic acid
- Unbound niacin by HPLC, which indicates incomplete reaction or breakdown.
- Related substances
- Partially esterified inositol nicotinates and other impurities by HPLC.
- Loss on drying and residue on ignition
- Moisture and inorganic residue.
- Heavy metals and microbiology
- Lead, arsenic, cadmium and mercury by ICP-MS, plus total plate count, yeast and mold.
Storage, lots and expiry
Storage and shelf life
Store inositol hexanicotinate in tightly closed containers in a cool, dry place away from light. It is stable under normal conditions, but moisture can cause hydrolysis of the ester. Shelf life is set by the supplier's specification, and aged stock is retested for assay and free nicotinic acid.
Lots and expiry dates
Record the assay and free nicotinic acid result for each lot, and label calculations should use the supplier's stated niacin equivalent. Keep it on a separate item code from niacin, niacinamide and plain inositol.
Regulatory status
Facts from regulators and standards bodies, each linked to its source.
Health Canada's Multi-Vitamin/Mineral Supplements monograph for natural health products lists inositol hexanicotinate among the source ingredients for niacin (Table 1).
Source: webprod.hc-sc.gc.ca (opens in a new tab)The same monograph also lists inositol hexanicotinate as a source of inositol, which it classes as a complementary ingredient that must be combined with at least one ingredient from its Tables 1 to 3.
Source: webprod.hc-sc.gc.ca (opens in a new tab)21 CFR 101.9(c)(8)(iv) sets the Reference Daily Intake for niacin at 16 mg NE for adults and children 4 years and older.
Source: ecfr.gov (opens in a new tab)
This is general information, not regulatory advice. Status differs by country and by how the ingredient is used, so check the rules for your product and market.
Inositol hexanicotinate suppliers
Manufacturers and distributors whose own websites say they sell it.
We are checking inositol hexanicotinate suppliers now
Every listing is checked against the supplier’s own website before it goes live, so this list fills in over the coming weeks. The specs and COA checklist above are ready today.
Sell inositol hexanicotinate? Request a listingFrequently asked questions
What forms of inositol hexanicotinate can brands buy?
Common forms include uSP or pharmaceutical grade powder, granulated grades and blends. Ask each supplier for the specification sheet of the exact grade they quote.
What should the COA for inositol hexanicotinate include?
Expect assay, free nicotinic acid, related substances, loss on drying and residue on ignition and heavy metals and microbiology, each with its method, specification and result for that lot.
How should inositol hexanicotinate be stored?
Store inositol hexanicotinate in tightly closed containers in a cool, dry place away from light. It is stable under normal conditions, but moisture can cause hydrolysis of the ester. Shelf life is set by the supplier's specification, and aged stock is retested for assay and free nicotinic acid.
What is the regulatory status of inositol hexanicotinate?
Health Canada's Multi-Vitamin/Mineral Supplements monograph for natural health products lists inositol hexanicotinate among the source ingredients for niacin (Table 1). The same monograph also lists inositol hexanicotinate as a source of inositol, which it classes as a complementary ingredient that must be combined with at least one ingredient from its Tables 1 to 3. 21 CFR 101.9(c)(8)(iv) sets the Reference Daily Intake for niacin at 16 mg NE for adults and children 4 years and older.
More vitamins and minerals
- Magnesium GlycinateMagnesium bisglycinate · Magnesium bisglycinate chelate
- Vitamin CL-ascorbic acid · Ascorbic acid
- Vitamin D3Cholecalciferol · Colecalciferol
- ZincZinc citrate · Zinc gluconate
- Vitamin A palmitateRetinyl palmitate · Retinol palmitate
- Vitamin A acetateRetinyl acetate · Retinol acetate
- Beta-caroteneβ-Carotene · all-trans-beta-carotene
- Vitamin D2Ergocalciferol · Calciferol
- Vitamin E (d-alpha tocopherol)d-alpha-tocopherol · RRR-alpha-tocopherol
- Mixed tocopherolsTocopherols concentrate, mixed · Mixed tocopherol concentrate
- Vitamin K1Phylloquinone · Phytonadione
- Vitamin K2 (MK-7)Menaquinone-7 · MK-7
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