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Benfotiamine

Benfotiamine suppliers and sourcing guide

Benfotiamine (S-benzoylthiamine O-monophosphate) is a synthetic, fat-soluble derivative of thiamine (vitamin B1). It is made by chemical synthesis from thiamine, which is phosphorylated and then S-benzoylated with its thiazole ring opened, and the product is crystallized and dried. It is a white crystalline powder that dissolves poorly in water, and brands buy it as powder for capsules and tablets.

See suppliersWhat to ask for on the COA
Also known as
S-Benzoylthiamine O-monophosphate · CAS 22457-89-2
Facts checked
November 2026

Forms and grades of benfotiamine

Suppliers sell different products under the same name. Specify the one you need.

  • Standard powder

    Crystalline benfotiamine at high stated purity, for capsules and tablets.

  • Granular or direct-compression grade

    Granulated material with better flow for tableting.

  • Micronized grade

    Finer particle size for more even blending at lower doses.

  • Pharmacopeia-tested grade

    Material tested to a national pharmacopeia monograph, such as the Japanese Pharmacopoeia, where the supplier offers it.

What to check on the COA

Compare each result with your own specification when the lot arrives.

Assay (HPLC)
Benfotiamine content on a dried basis by HPLC.
Identity
Infrared spectrum against a benfotiamine reference standard.
Related substances
Thiamine, thiamine monophosphate and other synthesis impurities by HPLC.
Loss on drying
Moisture content against the supplier specification.
Residual solvents and heavy metals
Synthesis solvents by GC and lead and other elemental impurities by ICP-MS.
Microbiology
Total aerobic count, yeast and mold and specified pathogens.

Storage, lots and expiry

Storage and shelf life

Store benfotiamine tightly closed in a cool, dry place protected from light. It is a stable powder under these conditions, and suppliers set shelf life or a retest date, with HPLC assay and related substances as the usual retest checks.

Lots and expiry dates

Record assay and related substances for each lot, and keep it as a separate item from thiamine salts, since the amount of thiamine per gram is different.

Regulatory status

Facts from regulators and standards bodies, each linked to its source.

This is general information, not regulatory advice. Status differs by country and by how the ingredient is used, so check the rules for your product and market.

Benfotiamine suppliers

Manufacturers and distributors whose own websites say they sell it.

We are checking benfotiamine suppliers now

Every listing is checked against the supplier’s own website before it goes live, so this list fills in over the coming weeks. The specs and COA checklist above are ready today.

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Frequently asked questions

What forms of benfotiamine can brands buy?

Common forms include standard powder, granular or direct-compression grade, micronized grade and pharmacopeia-tested grade. Ask each supplier for the specification sheet of the exact grade they quote.

What should the COA for benfotiamine include?

Expect assay (HPLC), identity, related substances, loss on drying, residual solvents and heavy metals and microbiology, each with its method, specification and result for that lot.

How should benfotiamine be stored?

Store benfotiamine tightly closed in a cool, dry place protected from light. It is a stable powder under these conditions, and suppliers set shelf life or a retest date, with HPLC assay and related substances as the usual retest checks.

What is the regulatory status of benfotiamine?

Health Canada's Multi-Vitamin/Mineral Supplements monograph lists benfotiamine as a source ingredient for thiamine (vitamin B1).

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