Bacillus coagulans
Bacillus coagulans is a lactic acid-producing, spore-forming bacterium; it was reclassified as Weizmannia coagulans in 2020 and later as Heyndrickxia coagulans, and was once sold as Lactobacillus sporogenes. It is grown by fermentation, induced to form spores, then harvested and dried. Because spores withstand heat, it is used in baked goods, hot drinks and shelf-stable foods as well as supplements, bought as a named strain at a stated CFU per gram.
Suppliers sell different products under the same name. Specify the one you need.
Dried spores of a named strain at a high count stated in billions of CFU per gram.
Spores diluted with maltodextrin or another carrier to a fixed lower count for easier dosing in foods and capsules.
Grades offered for baked goods, pasta, hot beverages and other foods made with heat, with the supplier's data on count retention through the process.
Heat-inactivated cells or spores sold as a separate ingredient from the live spore powder.
Compare each result with your own specification when the lot arrives.
Spore powders are more stable than freeze-dried lactobacilli and are usually stored sealed at room temperature, cool and dry, away from humidity; follow the supplier's stated conditions. Keep containers closed between uses to keep moisture out. Shelf life is set by the supplier from spore count stability data, and aged stock is retested for count.
Record the actual spore count, strain and carrier for each lot, and check that the count method (heat-shock temperature and medium) matches the one in your specification, since methods change results. Rotate stock FEFO.
Facts from regulators and standards bodies, each linked to its source.
FDA's GRAS Notice Inventory lists GRN 399 for a preparation of Bacillus coagulans strain GBI-30, 6086 spores, notified by Ganeden Biotech; it closed on July 31, 2012 with FDA having no questions. The notice covers that notifier's strain and intended use only.
Source: hfpappexternal.fda.gov (opens in a new tab)FDA's GRAS Notice Inventory lists GRN 1221 for Heyndrickxia coagulans NRRL B-67744, notified by Microbial Discovery Group; it closed on June 9, 2025 with FDA having no questions. The notice covers that notifier's strain and intended use only.
Source: hfpappexternal.fda.gov (opens in a new tab)Health Canada's Probiotics monograph lists Bacillus coagulans among the live microorganisms excluded from the monograph, so a natural health product with it cannot use the compendial route.
Source: webprod.hc-sc.gc.ca (opens in a new tab)FDA's draft guidance on dietary supplements containing live microbials states its intent to exercise enforcement discretion so that firms may declare live microbial quantity in colony forming units (CFUs), in addition to the weight declaration required by regulation.
Source: fda.gov (opens in a new tab)This is general information, not regulatory advice. Status differs by country and by how the ingredient is used, so check the rules for your product and market.
Manufacturers and distributors whose own websites say they sell it.
Manufacturer · Hyderabad, India
Sells it as Unique IS-2
Indian probiotic manufacturer in Hyderabad’s Genome Valley that supplies spore-forming and other probiotic strains in bulk and as contract-made finished formats.
Suppliers are in alphabetical order and none pays to appear. Each claim is checked against the supplier’s own website on the date shown. Ask for the specification sheet and a recent COA before you order, and confirm details with the supplier.
Common forms include spore powder concentrate, standardized dilution, food-processing grade and inactivated. Ask each supplier for the specification sheet of the exact grade they quote.
Expect spore count (CFU/g), identity, contaminant microbiology, moisture and heavy metals, each with its method, specification and result for that lot.
Spore powders are more stable than freeze-dried lactobacilli and are usually stored sealed at room temperature, cool and dry, away from humidity; follow the supplier's stated conditions. Keep containers closed between uses to keep moisture out. Shelf life is set by the supplier from spore count stability data, and aged stock is retested for count.
FDA's GRAS Notice Inventory lists GRN 399 for a preparation of Bacillus coagulans strain GBI-30, 6086 spores, notified by Ganeden Biotech; it closed on July 31, 2012 with FDA having no questions. The notice covers that notifier's strain and intended use only. FDA's GRAS Notice Inventory lists GRN 1221 for Heyndrickxia coagulans NRRL B-67744, notified by Microbial Discovery Group; it closed on June 9, 2025 with FDA having no questions. The notice covers that notifier's strain and intended use only. Health Canada's Probiotics monograph lists Bacillus coagulans among the live microorganisms excluded from the monograph, so a natural health product with it cannot use the compendial route. FDA's draft guidance on dietary supplements containing live microbials states its intent to exercise enforcement discretion so that firms may declare live microbial quantity in colony forming units (CFUs), in addition to the weight declaration required by regulation.
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