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Chlorphenesin

Chlorphenesin suppliers and sourcing guide

Chlorphenesin is a synthetic glycerol ether, 3-(4-chlorophenoxy)-1,2-propanediol, made by reacting 4-chlorophenol with a glycerol derivative such as glycidol or 3-chloro-1,2-propanediol and crystallizing the product. It is a white crystalline powder that dissolves in warm water, glycols and alcohol. In personal care it is used at low levels as a preservative, usually combined with other preservatives such as phenoxyethanol, and brands buy it as a powder.

See suppliersWhat to ask for on the COA
Also known as
3-(4-Chlorophenoxy)-1,2-propanediol · p-Chlorophenyl alpha-glyceryl ether · CAS 104-29-0
Facts checked
November 2026

Forms and grades of chlorphenesin

Suppliers sell different products under the same name. Specify the one you need.

  • Crystalline powder

    White to off-white powder at high purity, the standard form; it is usually pre-dissolved in warm water or a glycol.

  • Preservative blends

    Chlorphenesin premixed with phenoxyethanol, caprylyl glycol or other preservatives, sold under trade names as ready-to-use systems.

  • Pharmaceutical grade

    Higher-documentation grades made for drug use, with additional impurity testing.

What to check on the COA

Compare each result with your own specification when the lot arrives.

Assay (HPLC)
Chlorphenesin content, usually 99 percent or more.
4-Chlorophenol
Residual 4-chlorophenol, the main starting material, reported by HPLC or GC against a low limit.
Melting range and identity
Melting range and IR spectrum, a quick check on identity and purity.
Loss on drying
Moisture content of the powder.
Heavy metals
Lead, arsenic and other metals by ICP-MS or ICP-OES against the supplier's specification or the Food Chemicals Codex (FCC) limits.

Storage, lots and expiry

Storage and shelf life

Store chlorphenesin sealed in a cool, dry area away from light and strong oxidizers. The powder is stable when dry; keep containers closed to prevent caking. Shelf life comes from the supplier's specification, with retest of assay and residual 4-chlorophenol for older lots.

Lots and expiry dates

Record assay and residual 4-chlorophenol for each lot. If you buy a blend, record its composition and lot so the full preservative system can be traced on the label.

Regulatory status

Facts from regulators and standards bodies, each linked to its source.

This is general information, not regulatory advice. Status differs by country and by how the ingredient is used, so check the rules for your product and market.

Chlorphenesin suppliers

Manufacturers and distributors whose own websites say they sell it.

We are checking chlorphenesin suppliers now

Every listing is checked against the supplier’s own website before it goes live, so this list fills in over the coming weeks. The specs and COA checklist above are ready today.

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Frequently asked questions

What forms of chlorphenesin can brands buy?

Common forms include crystalline powder, preservative blends and pharmaceutical grade. Ask each supplier for the specification sheet of the exact grade they quote.

What should the COA for chlorphenesin include?

Expect assay (HPLC), 4-Chlorophenol, melting range and identity, loss on drying and heavy metals, each with its method, specification and result for that lot.

How should chlorphenesin be stored?

Store chlorphenesin sealed in a cool, dry area away from light and strong oxidizers. The powder is stable when dry; keep containers closed to prevent caking. Shelf life comes from the supplier's specification, with retest of assay and residual 4-chlorophenol for older lots.

What is the regulatory status of chlorphenesin?

Health Canada's Natural Health Products Ingredients Database lists chlorphenesin (3-(4-chlorophenoxy)-1,2-propanediol) with the non-medicinal purpose "preservative antimicrobial". The same database entry restricts that non-medicinal use to topical products.

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